Factors associated with negative conversion of viral RNA in hospitalized children infected with SARS-CoV-2 Omicron variant in Shanghai, China: a retrospective analysis.

OBJECTIVES: This study aimed to identify the related risk factors and potential predictors of SARS-CoV-2 RNA negative conversion by describing the dynamics of viral shedding in infected children admitted to two hospitals from Shanghai during the Omicron variant outbreak. METHODS: This retrospective cohort included laboratory-confirmed cases of SARS-CoV-2 infection from Shanghai between March 28 and May 31, 2022. Clinical characteristics, personal vaccination, and household vaccination rates were collected through electronic health records and telephone interviews. RESULTS: A total of 603 paediatric patients confirmed to have COVID-19 were included in this study. Both univariate and multivariate analyses were performed to filter independent factors for the duration to viral RNA negative conversion. Data on the redetection of SARS-CoV-2 in the patients after they showed negative results on the RT‒PCR test (intermittent negative status) were also analysed. The median duration of virus shedding was 12 (interquartile range, IQR: 10-14) days. The severity of clinical outcome, personal vaccination-2doses, household vaccination rates, and abnormal defecation were factors indecently affecting negative conversion of SARS-CoV-2 RNA, suggesting that patients who had abnormal defecation or with more severe conditions would have delayed virological clearance, while patients who previously had 2 doses of vaccination or had higher household vaccination rates would have accelerated virological clearance. Loss of appetite (odds ratio (OR): 5.343; 95% CI: 3.307-8.632) and abnormal defecation (OR: 2.840; 95% CI: 1.736-4.645) were significantly associated with intermittent negative status. CONCLUSION: These findings could provide clues for the early identification of paediatric patients with prolonged viral shedding and could enrich the evidence for the development of prevention and control strategies, especially vaccination policies for children and adolescents.

The impact of paid social Q&A on panic buying and digital hoarding at the stage of coexistence with COVID-19: The moderating role of sensitivity to pain of payment.

The worldwide disaster caused by COVID-19 and its variants has changed the behavior and psychology of consumers. Panic buying and hoarding of various commodities continue to emerge in our daily life. Meanwhile, many scholars have focused on the causes of panic buying and hoarding of physical products like daily necessities and food during the outbreak of COVID-19. In fact, the phenomenon of panic buying and digital hoarding of paid social Q&A and other digital content products is very prominent, both in the outbreak period of COVID-19 epidemic and the current coexistence stage. However, the existing literature lacks empirical research to explore this phenomenon, and the psychological mechanism behind it has not been clearly revealed. Therefore, at the current stage of coexistence with COVID-19, based on the SOBC framework, we developed a theoretical model and explored the causes of panic buying and digital hoarding in paid social Q&A. The data collected from 863 paid social Q&A users in China are empirically tested. The results show that the characteristics of paid social Q&A (usefulness, ease of use, professionalism and value) can cause emotional contagion among platform users, activate their willingness to pay, and finally lead to digital hoarding and panic buying behavior of COVID-19 co-existence stage. In addition, the sensitivity to pain of payment moderates the relationship between emotional contagion and willingness to pay. Compared with the spendthrifts, the tightwads are more willing to pay. The conclusions will have positive significance for improving the retail service of digital content platform and promoting the consumption of digital content.

A novel mRNA vaccine, SYS6006, against SARS-CoV-2.

The development of vaccines that can efficiently prevent the infection of SARS-CoV-2 is necessary to fight the COVID-19 epidemic. mRNA vaccine has been proven to induce strong humoral and cellular immunity against SARS-CoV-2. Here, we studied the immunogenicity and protection efficacy of a novel mRNA vaccine SYS6006. High expression of mRNA molecules in 293T cells was detected. The initial and boost immunization with a 21-day interval was determined as an optimal strategy for SYS6006. Two rounds of immunization with SYS6006 were able to induce the neutralizing antibodies against the SARS-CoV-2 wild-type (WT) strain, and Delta and Omicron BA.2 variants in mice or non-human primates (NHPs). A3rd round of vaccination could further enhance the titers of neutralization against Delta and Omicron variants. In vitro ELISpot assay showed that SYS6006 could induce memory B cell and T cell immunities specifically against SARS-CoV-2 in mice. FACS analysis indicated that SYS6006 successfully induced SARS-CoV-2-specific activation of T follicular helper cell (Tfh) and Th1 cell, and did not induce CD4+Th2 response in NHPs. SYS6006 vaccine could significantly reduce the viral RNA loads and prevent lung lesions in Delta variant infected hACE2 transgenic mice. Therefore, SYS6006 could provide significant immune protection against SARS-CoV-2.

The impact of paid social Q&A on panic buying and digital hoarding at the stage of coexistence with COVID-19: The moderating role of sensitivity to pain of payment

The worldwide disaster caused by COVID-19 and its variants has changed the behavior and psychology of consumers. Panic buying and hoarding of various commodities continue to emerge in our daily life. Meanwhile, many scholars have focused on the causes of panic buying and hoarding of physical products like daily necessities and food during the outbreak of COVID-19. In fact, the phenomenon of panic buying and digital hoarding of paid social Q&A and other digital content products is very prominent, both in the outbreak period of COVID-19 epidemic and the current coexistence stage. However, the existing literature lacks empirical research to explore this phenomenon, and the psychological mechanism behind it has not been clearly revealed. Therefore, at the current stage of coexistence with COVID-19, based on the SOBC framework, we developed a theoretical model and explored the causes of panic buying and digital hoarding in paid social Q&A. The data collected from 863 paid social Q&A users in China are empirically tested. The results show that the characteristics of paid social Q&A (usefulness, ease of use, professionalism and value) can cause emotional contagion among platform users, activate their willingness to pay, and finally lead to digital hoarding and panic buying behavior of COVID-19 co-existence stage. In addition, the sensitivity to pain of payment moderates the relationship between emotional contagion and willingness to pay. Compared with the spendthrifts, the tightwads are more willing to pay. The conclusions will have positive significance for improving the retail service of digital content platform and promoting the consumption of digital content.

Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition).

Since December 2019, there has been an outbreak of novel coronavirus (2019-nCoV) infection in China. Two cases of neonates with positive 2019-nCoV tests have been reported. Due to the immature immune system and the possibility of vertical transmission from mother to infant, neonates have become a high-risk group susceptible to 2019-nCoV, which emphasize a close cooperation from both perinatal and neonatal pediatrics. In neonatal intensive care unit (NICU), to prevent and control infection, there should be practical measures to ensure the optimal management of children potentially to be infected. According to the latest 2019-nCoV national management plan and the actual situation, the Chinese Neonatal 2019-nCoV expert working Group has put forward measures on the prevention and control of neonatal 2019-nCoV infection.